In a presentation to the Southern Growth Policy Board’s 1997 Conference on the Future of the South, argues that partnership, including Public Private Partnerships, for the 21st century needs to be about winning combinations. Describes the change in resources that generate, prosperity, jobs and meaningful futures from natural endowments and geographic location to advanced technologies based on knowledge-based investments, highly skilled personnel and abundant financial assets. Describes breakthrough partnering between the public and private sector as the key to developing technology that will generate wealth, prosperity and newer, higher paying jobs in the future. Describes four freedoms necessary to achieve breakthrough partnering: exchange of ideas, access, trade and enterprise. Argues that bold, innovative leadership is required to reshape and restructure institutions to fit the new economy.