This monograph brings together selected articles and IC2 Institute research on the topic of regional economic development through the growth of locally founded (or "indigenous") companies, in contrast to development relying primarily on industrial relocation. It provides a framework for understanding and implementing new approaches to economic growth and diversification at the community and regional levels. Talent, technology, capital and know-how are all required to build successful ventures. There must also be institutional foundations that support the entrepreneurial process through innovative infrastructures. These infrastructures include educational institutions, public and private sector entities, financial institutions and business networks. In addition, newer institutional relationships are necessary to link effectively business, government and academia.